I have used 2 bottles of facetheory Regencalm Serum Pro. And liked it very much. My skin feels smoother and I think more refined and clearer textured, and helps with redness and wrinkles after the first time I used it. I bought just Regenecalm Serum, (not Pro) and am using that now. It has 2%, instead of 3% Retinol. There is some differnece I notice, I think I like the Pro better. But got a sale price on the the latter. Both types are very nice and helpful on my skin. I like the that they are mild and my skin doesn't have any bad reactions. I tend to use it all over my face and neck, not just spots.