I have used these for a few years, it's helped me with my Neurological Neuropathic Pain Condition along with the complications associated with this and my osteoarthritis which I've had for many years, even though I've put on weight from all the medication over the years because of the neurological condition, which I now no longer use, after discussions with my pain consultants and GP I've gone back to alternatives which I've used for at least 40 years, I'd recommend using anything alternative after speaking with your medical professional,I have normal blood pressure, no diabetes and other things that might be associated with someone overweight.